Protects against common cold viruses

Protects against common cold viruses

ColdZyme® is a mouth spray that treats and alleviates common cold. ColdZyme® is unique as it works immediately to create a protective barrier between you and the cause of the cold, the actual common cold viruses.

ColdZyme® has a triple action:

  • PROTECTS against common cold viruses
  • Helps SHORTEN THE DURATION of a cold if used at the early stage of infection
  • ALLEVIATES common cold symptoms

ColdZyme® can be used before and during infection by adults and children from 4 years.
ColdZyme® is a CE-marked medical device, How ColdZyme® works

How ColdZyme® works

ColdZyme® is unique because it acts against the cause of the cold, the cold virus itself. ColdZyme® is easy to use and acts immediately by forming a protective barrier in the oral cavity and throat.
The barrier works by capturing cold viruses and blocking the virus' ability to infect cells so that the body can get rid of the virus naturally. ColdZyme® protects against cold viruses, relieves cold symptoms and can shorten the course of the disease when used at the early stages of a cold. ColdZyme® is available in 20ml and 7ml packs.

The ColdZyme® barrier uses glycerol to provide a protective barrier



Glycerol creates an effective barrier in the throat that traps viruses.



Glycerol inhibits the viruses' ability to bond, helping block them from infecting cells.



The ColdZyme® barrier protects the oral cavity and throat.

When to use ColdZyme®

Start using ColdZyme® as soon as possible after the symptoms of common cold appear or if you are at risk of possible exposure to common cold viruses.
Continue to use ColdZyme® until the symptoms are relieved.

When to use ColdZyme®

The above symptoms are examples of first signs of a common cold

How to use ColdZyme®

The use of ColdZyme® is very easy, just read the instructions for use below. Of course, if you need more information on ColdZyme®, read on.

Coldzyme® video

1. Open your mouth and aim the nozzle towards your throat

2. Press down on the pump and spray 2 times (1 dose) every second hour up to 6 times daily during the time you are exposed to the cold virus or until symptoms are relieved.

instructions for use

Product Information

ColdZyme® 20ml / 7ml

Glycerol, water, a natural enzyme - cod trypsin, ethanol, calcium chloride, trometamol and menthol.

ColdZyme® is lactose-free, sugar-free, gluten-free and contains no preservatives.

Storage and sustainability:
ColdZyme® must be stored at room temperature, max. 25°C.
The shelf life is 36 months from the date of manufacture.

For expiration dates, see the bottle or the underside of the package.
The same shelf life applies to opened and unopened bottles.

Buy now
Coldzyme® 20ml Coldzyme® 7ml
What is Trypsin?

What is trypsin?

In the 1970s, the Icelandic researcher Professor Jon Bragi Bjarnason noticed that staff in the fish cleaning company had unusually whole and soft hands.

Given that they cleaned fish, their hands should rather have been cracked and sore. Was there anything in the fish that seemed protective?

The answer was yes.

The research group was able to show that in some cold-adapted marine organisms such as cod there is an enzyme with good protective barrier properties. The development work eventually led to a world patent for the marine enzyme cold-adapted trypsin. The enzyme is extracted as a by-product in the preparation of cod and therefore does not burden the marine ecosystem.

What is cold?

What is a cold?

Respiratory viral infections, also known as the common cold, are the most common infections in humans. Several viruses have been associated with the common cold, of which rhinovirus is the most common.1
The incubation period of an infectious disease is the time between infection and symptom onset. The incubation period varies depending on the type of virus, ranging form half a day to over a week for some viruses.2

Common symptoms include a runny or stuffy nose and sore throat. Symptoms may also include a mild cough and headache with fever. An ordinary cold usually lasts for fewer than ten days and, on average, people have two to five colds per year.3

Children are the group who catch colds most often – 7 to 10 colds per year3 – but this frequency declines with age.

1 Wat, Dennis. The common cold: a review of the literature, European Journal of Internal Medicine. 15 (2004): 79-88
2 Lessler, Justin et al. Incubation periods of acute respiratory viral infections: a systematic review,
The Lancet Infectious Diseases, Volume 9, Issue 5, 291-300.
3 Hull D, et al. Effects of creating a non-specific, virus-hostile environment in the nasopharynx on symptoms and duration of common cold. Acta Otorhinolaryngol Ital. 2007 Apr; 27(2): 73-7.

How to prevent common cold infection

How to prevent common cold infection

Recommendations to reduce the risk of infection from common cold and other respiratory viruses:

  • Keep a distance of at least 1.5 meters between you and people with respiratory symptoms including coughing and sneezing.
  • Wash your hands regularly with soap under warm running water for at least 20 seconds or use an alcohol based hand sanitiser if hand washing is not practical. This is especially important after sneezing, coughing or coming into contact with people who have respiratory symptoms.
  • Always sneeze or cough into the crook of your arm.
  • Clean or disinfect potentially contaminated objects and surfaces.
  • Avoid touching your mouth, nose and eyes.
  • Dispose of used tissues immediately.
  • Stay home if you feel unwell so you don’t pass an infection on to others.
  • Always try to maintain a healthy diet and lifestyle.

Myths about colds and flu

There are a range of common misconceptions about catching cold and how to avoid them, find out which of these myths might have some truth behind them.

The ColdZyme® difference



All ColdZyme® product packaging is recyclable through most household recycling schemes. The trypsin enzyme in ColdZyme® is sustainably sourced as a by-product of the fishing industry.



ColdZyme® is made by Enzymatica, a Swedish life science company that develops and sells medical devices based on barrier technology that utilises innovative natural marine enzymes (e.g. trypsin in ColdZyme®).

Quality & Safety

Quality & Safety

Enzymatica develops health care products in an environment that is regulated by EU laws, directives, and standards. We test and document throughout the entire product life cycle to help ensure it lives up to its efficacy and performance claims.


Where to buy?

ColdZyme® is available from:

Frequently asked questions about ColdZyme®

What disease conditions can ColdZyme® help with?

ColdZyme® is intended to be used against colds during virus exposure and can shorten the cold if used early in the course of the disease.
ColdZyme® relieves cold symptoms.

Where can I get ColdZyme®?

ColdZyme® is available from Boots, independent pharmacies and also Amazon.

How to use ColdZyme®?

Point the nozzle towards the throat and spray 2 puffs (1 dose) every two hours to help protect against infection or until the symptoms are gone.

Can anyone use ColdZyme®?

ColdZyme® Mouth Spray can be used by adults and children over the age of 4, provided they are not hypersensitive/allergic to any of the ingredients.

How does ColdZyme® work?

ColdZyme® Mouth Spray works by creating a protective barrier on the mucous membrane in the oral cavity and throat. The barrier reduces the ability of the virus to bind to the cells in the mucous membrane and cause illness.

Is ColdZyme® a medicine?

No. ColdZyme® Mouth Spray is a CE-marked medical device that works by creating a temporary, local, protective barrier on the surface of the mucous membrane in the oral cavity and throat. Unlike medicines, it has no pharmacological, metabolic or immunological effect.

Can ColdZyme® be used during pregnancy and lactation?

No clinical studies have been conducted on the use of ColdZyme® Mouth Spray during pregnancy and breastfeeding, so always consult a doctor before use.


  • Do not use ColdZyme® if you are hypersensitive/allergic to any of the ingredients.
  • Do not use the product during pregnancy or lactation, as there is no clinical information.
  • Do not use the product after surgery in the mouth and/or throat until the wound is healed, without consulting a doctor.
  • Do not inhale when applying the spray as it may cause irritation of the airways, resulting in cough and hoarseness.
  • Keep out of reach of children, to prevent accidents with small parts.
  • Consult a doctor if you have a high fever or if your symptoms are more severe than those of a normal common cold; they could be due to something else.
  • To avoid spread of disease, the product should only be used by one user.
  • For optimal effect, do not eat or drink within 20 minutes after use.
  • Do not use if packaging is damaged or opened.

Contact us

You can contact us on any matter.
We are here to ensure your safety, if you are wondering about something that you have not found on this page, write to us by selecting the topic of the conversation from the form below.

Product enquiries
Product enquiries Product enquiries General enquiries Complaints

Press, Media and investor relations

Press, Media and investor relations